What Does Science Have To Say About Microdose? 

Microdosing has become increasingly popular for those looking for new ways to boost their cognitive abilities, creativity, and general wellness. 

It involves taking tiny amounts of substances such as psychedelics or edibles online, usually just a small fraction of a usual recreational dose. 

While there are many personal stories about the benefits of microdosing, it’s important to explore what scientific research reveals about this trend.


Scholars from the University of Toronto and York University in Canada claim that microdosing isn’t limited to common substances but extends to mescaline, DMT, amphetamines, Salvia divinorum, and research chemicals. Unlike usual psychedelic use, people who do microdosing often follow a consistent schedule. For instance, they follow dosing every 3 days.

What is the Amount of Microdosing?

A journal published in Neuroscience & Biobehavioral Reviews explains that determining the exact amount for a microdose is challenging due to a lack of consistent criteria among researchers. The commonly mentioned definition is a dose ranging from about one-tenth to one-twentieth of a typical recreational dose. Yet, this range needs to be clarified for scientific purposes. 

Several reasons contribute to this uncertainty:

Variation in Effects

Substantial variation exists in pharmacological and subjective effects within and across substances. Establishing equivalent dose ranges for different drugs, species, preparation methods, and individual responses is challenging.

Subjective Effects Definition

There’s disagreement on what effects microdosing should have. It’s often called ‘sub-perceptual,’ meaning users shouldn’t notice any effects, but studies show people do experience slight changes. The term ‘sub-hallucinogenic’ might be more accurate for these effects.

It’s hard to define a microdose because there are no set rules exactly, the substances vary, and people react differently.

Why is Microdosing Popular?

Microdosing’s rise in popularity can be traced back to James Fadiman’s book, ‘The Psychedelic Explorers Guide’ (2011), which introduced the term and sparked widespread interest. This book sparked a lot of interest in microdosing, which was happening at the same time as people became more accepting of psychedelics. There’s been more use and new research centers for psychedelics.

The interest in psychedelics is mainly because of studies on their health benefits. While many studies focus on the effects of larger doses in clinics, research on microdosing shows how tiny, regular doses can help improve mental function and well-being in healthy individuals.

Microdosing is getting more popular because of its claimed benefits and more research into it. It’s important to separate real evidence from just stories as microdosing gets more attention to understand what it does.

Impact of Microdosing

Neurological Impact

  • Studies suggest that psychedelics may influence serotonin receptors, which affects mood regulation.
  • Increased connectivity in certain brain regions is observed, potentially explaining enhanced creativity.

Mood Enhancement

  • Research indicates a potential link between microdosing and improved mood.
  • Serotonin modulation may play a role in reducing symptoms of depression and anxiety.

Cognitive Benefits

  • Cognitive flexibility and problem-solving skills may see improvements.
  • Increased neuroplasticity is associated with enhanced learning and memory.

Creativity Boost

  • Anecdotal evidence and some studies propose that microdosing may stimulate creative thinking.
  • Enhanced divergent thinking and increased openness to new experiences are reported.

Dosage Matters

  • The effectiveness of microdosing depends on the substance and the individual’s sensitivity.
  • A fine balance is important, as too much can lead to unwanted effects.

Risks and Challenges of Microdosing

Individual Variability

Responses to microdosing vary widely among individuals. Factors like genetics, mental health, and overall health can influence outcomes.

Limited Research

The scientific understanding of microdosing is still in its early stages. Long-term effects and potential risks need to be well-established.

Selecting the Right Microdose Product

Product Active Ingredient Dosage Form Highlights
Microdose Capsules Psilocybin Psilocybin Precise dosing, convenient, and discreet
Liquid LSD Microdose LSD LSD (Lysergic Acid Diethylamide) Customizable dosing, and rapid onset
Psilocybin Chocolate Psilocybin Tasty, easy to consume, and discreet

If you are looking for quality weed edibles for microdosing online, here are the top 3 selections for you:

OneStop’s Very Cherry THC Gummies 500mg

OneStop’s Very Cherry THC Gummies 500mg provides a flavourful edible experience without the high cost often associated with health and wellness products. Each package contains 500mg of THC, divided into 10 gummies of 50mg, each with a blend of taste and quality. 

Potluck’s Infused Chocolate – Maple Bacon – 300mg THC

Potluck’s Infused Chocolate – Maple Bacon – 300mg THC is a product designed for contemporary cannabis enthusiasts. This chocolate bar combines natural flavours and full-spectrum cannabis oils. The Maple Bacon variant is divided into twelve 25mg pieces.

Potluck Extracts’ Grape Gummies (1:1) – 100mg THC / 100mg CBD

Potluck Extracts offers Grape Gummies in a 1:1 ratio – containing 100mg THC and 100mg CBD. They’re made with full-spectrum cannabis, CBD oils, and natural flavours. Each gummy provides a balanced mix of 10mg CBD and 10mg THC for a pleasant and well-rounded experience.

How to Microdose Weed Edibles

To microdose weed edibles, start with a low dose (1-2.5 mg THC), choose accurately labelled products, wait for effects before taking more, track your doses, maintain a consistent schedule, ensure a comfortable setting. The goal is subtle benefits without a strong high.

Microdose Your Way Into the Psychedelic World

Science is starting to reveal the possible benefits of microdosing, but it’s wise to proceed with care. People react differently to it, and we don’t fully understand the long-term effects yet.

If you’re considering microdosing, starting with small doses is always a good idea. It’s also important to talk to healthcare professionals for guidance.

Frequently Asked Questions

How is a microdose different from a regular dose?

A microdose is significantly smaller than a regular dose of a substance. Specifically:


A microdose is about 1/10th to 1/20th of a regular dose. For psychedelic substances like psilocybin or LSD, a regular dose causes full psychedelic effects, while a microdose aims to be sub-perceptual, meaning it doesn’t induce noticeable alterations in perception or mood.


Microdosing is done for different reasons than taking a regular dose. While a regular dose is intended for a full psychedelic experience, microdosing is used to enhance cognitive function, creativity, mood, and overall well-being without the intense sensory and psychological effects.


Microdoses are taken according to a schedule (like every third day), whereas a regular dose is taken less frequently due to its more intense effects.

How do I measure a microdose accurately?

To measure a microdose accurately:

  1. Understand how strong your substance is.
  2. Use a digital scale for solids or a calibrated dropper for liquids.
  3. Find out the recommended small dose for your substance.
  4. For very potent substances, dilute them in water or alcohol to measure easily.
  5. If using solids like mushrooms, grind them to powder and weigh the dose.
  6. Putting the powder in capsules can help with consistent dosing.
  7. Note down your doses and effects.
  8. Begin with the lowest dose and adjust as needed.

Can I microdose with other medications?

Always consult with a healthcare specialist before combining microdosing with any prescription or over-the-counter medications. Interactions can occur, and professional guidance is necessary.

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